Pérez-Ramírez and his group have now collaborated with other European scientists and an industry partner to develop just such a solid catalyst for a major chemical reaction, as the researchers report in Nature Nanotechnology ("A heterogeneous single-atom palladium catalyst surpassing homogeneous systems for Suzuki coupling"). Their catalyst is a molecular lattice composed of carbon and nitrogen atoms (graphitic carbon nitride) that features cavities of atomic dimensions into which the researchers placed palladium atoms.


Efficient catalyst for a Nobel-prizewinning reaction

By making tiny particles of this palladium-carbon-nitrogen material, the scientists were able to show that it catalyses what is known as the Suzuki reaction very efficiently. “In chemistry, forming a bond between two carbon atoms is often done using the Suzuki reaction,” says Sharon Mitchell, a scientist in Pérez-Ramírez’s lab. It was this reaction that won Japanese scientist Akira Suzuki and two colleagues the Nobel Prize in Chemistry 2010.

Thus far, the process in commercial scale has widely used soluble palladium catalysts. Earlier attempts to attach the soluble catalyst to a solid body always resulted in relatively unstable and inefficient catalysts.

Modeling of the catalyzed reaction (Video: ETH Zurich).


Considerably less waste

The ETH researchers’ new palladium catalyst is much more stable. For that reason, and because it does not dissolve in the reaction liquid, it can be used over a much longer time period. What’s more, the catalyst is much more cost-effective and around twenty times more efficient than the catalysts used today.

“That means the new catalyst not only cuts the costs of synthesising fine chemicals, it also reduces the consumption of palladium and decreases the amount of waste,” Pérez-Ramírez says. The catalyst might soon be ready for use in industry: the scientists claim that it should be easy to scale up catalyst production and use from the laboratory.

As the researchers point out, the use of graphitic carbon nitride as a solid catalyst is not limited to the Suzuki reaction. It should also be possible to populate the lattice with atoms of metals other than palladium in order to catalyse other syntheses. The ETH scientists will explore these possibilities in future research. They also plan to found a spin-off company to market this novel family of catalysts.

ETH Zurich. Posted: Jun 26, 2018.